Low FODMAP Diet in Patients With IBS

Jens Rikardt Andersen

Status: Completed

Conditions: Irritable Bowel Syndrome

Treatments: Other: Low FODMAP DIET = Diet with Low polyol, FOS and GOS

Study type: Interventional

Funder types: Other

Identifiers

NCT05618106

FODMAP

Details and patient eligibility

About

The aim was aimed to investigate if all carbohydrate groups eliminated in the Low FODMAP diet are equally important in relieving gastrointestinal symptoms in IBS.

in a randomized cross-over design to three different carbohydrate-modified diets: A) Low Polyol diet, B) Low FOS+GOS diet, and C) Low FODMAP diet for three months without wash-out-periods. Gastrointestinal symptoms, Quality of life was measured at baseline and after each intervention diet.

Full description

Low FODMAP diets contain 3 major types of carbohydrates to be avoided. The clasical diet is very difficult to maintain over longer periods of time. Therefore, we aimed to investigate if all carbohydrate groups in the Low FODMAP diet are equally important in relieving gastrointestinal symptoms in IBS.

Patients diagnosed with IBS according to the Rome III criteria were randomised in a cross-over design to three different carbohydrate-modified diets: A) Low Polyol diet, B) Low FOS+GOS diet, and C) Low FODMAP diet for a total of three months without wash-out-periods. Gastrointestinal symptoms were assessed by the Birmingham IBS questionnaire and adequate relief (IBS-AR). Quality of life was measured by the IBS Quality of Life Scale questionnaire (IBS-QOL). All registrations were performed at baseline and after each intervention diet.

Enrollment: 9 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• IBS diagnosed by the Rome III criteria and
• referred to the clinic for treatment by diet

Exclusion criteria

• Dementia
• lack of ability to speak Danish
• additional chronic diseases prevailing participation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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9 participants in 3 patient groups, including a placebo group

low FODMAP diet

Experimental group

Description:

Diet low in all kinds of FODMAPS

Treatment:

Other: Low FODMAP DIET = Diet with Low polyol, FOS and GOS

Low Fodmap diet but polyols allowed

Placebo Comparator group

Description:

Diet low in FOS and GOS

Treatment:

Other: Low FODMAP DIET = Diet with Low polyol, FOS and GOS

Low Fodmap diet but FOS and GOS allowed

Active Comparator group

Description:

Diet low in polyols

Treatment:

Other: Low FODMAP DIET = Diet with Low polyol, FOS and GOS