Low Frequency Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease

University of California (UC) Davis

Status: Completed

Conditions: Cognitive Impairment; Parkinson Disease

Treatments: Device: deep brain stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT03204526

693382

Details and patient eligibility

About

Prospective trial of low frequency deep brain stimulation of the ventral subthalamic nucleus to improve cognitive performance in patients with advanced Parkinson's disease. All study participants have undergone DBS implantation surgery as part of their routine care for motor manifestations of Parkinson's disease. In this study, a temporary low frequency period of stimulation will be applied to determine its effects on cognition.

Full description

In this randomized cross-over pilot study, our primary aim was to determine the effect of theta (5 Hz), and gamma (130 Hz) frequency stimulation in the ventral STN on cognitive control in patients with PD. This study provides a first look at frequency dependent modulation of cognitive function and provides important insights into the utility of DBS for non-motor symptoms of PD and other neuropsychiatric disorders.

Enrollment: 15 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Parkinson's disease, undergoing deep brain stimulation implantation as part of their routine management of motor symptoms.

Exclusion Criteria:

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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15 participants in 1 patient group

low frequency stimulation (LFS)

Experimental group

Description:

Low-frequency deep brain stimulation of the subthalamic nucleus

Treatment:

Device: deep brain stimulation