Low Glycemic Index and Load Diet for the Treatment of Acne

Centro Dermatológico Dr. Ladislao de la Pascua

Status: Completed

Conditions: Acne Vulgaris; Diet Modification

Treatments: Other: Low glycemic diet; Other: Normal diet; Drug: Doxycycline; Drug: Adapalene 0.1% Gel

Study type: Interventional

Funder types: Other

Identifiers

NCT03585140

106/2016

Details and patient eligibility

About

Clinical trial to determine the effect of adding a diet with low glycemic index and load to adults for the treatment of moderate acne. Adult patients with acne where recruited in two groups, A and B. Group A received a normal diet according to their metabolic status and group B received a diet with low glycemic index and load. Outcomes were measured at week 12.

Full description

Clinical trial to determine the effect of adding a diet with low glycemic index and load to adults for the treatment of moderate acne. Adult patients with acne where recruited in two groups, A and B. Both groups of treatment were treated with doxycycline 100 mg per day plus adapalene 0.1% gel daily for 12 weeks. During pharmacologic treatment, all patients had nutrition counseling monthly. Group A received a normal diet according to their metabolic status and group B received a diet with low glycemic index and load. At the end of the trial, the change in acne lesions count was analyzed and also their metabolic status. Quality of life was also measured.

Enrollment: 52 patients

Sex: Male

Ages: 18 to 25 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Having moderate inflammatory acne
• 18 to 25 years old
• Male
• Stable weight during the last 3 months

Exclusion criteria

• Previous or actual isotretinoin therapy
• Antibiotic therapy or during the last 3 months
• Therapy based on peelings, dermabrasion, laser or intense pulsed light during the last 6 months
• Endocrine disorders
• Drug and alcohol consumption during the last 6 months
• Tabacco use during the last 6 months
• Lactose intolerance
• Have eating disorders or gastrointestinal disorders
• Actual nutrition therapy
• Have chronic diseases that requires pharmacologic therapy
• Severe acne that requires isotretinoin therapy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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52 participants in 2 patient groups

Normal Diet

Active Comparator group

Description:

Participants will receive a normal diet according to their metabolic status.

Treatment:

Drug: Adapalene 0.1% Gel

Other: Normal diet

Drug: Doxycycline

Low glycemic diet

Experimental group

Description:

Participants will receive a low-glycemic index and load diet according to their metabolic status. Milk and vitamin supplements will be eliminated from the diet.

Treatment:

Drug: Adapalene 0.1% Gel

Other: Low glycemic diet

Drug: Doxycycline