Low Grade Inflammation in Childhood Obesity : an Independent Risk Factor for Endothelial Dysfunction

Universitair Ziekenhuis Brussel

Status

Completed

Conditions

Inflammation

Endothelial Dysfunction

Obesity, Childhood

Obesity

Cardiovascular Risk Factor

Treatments

Diagnostic Test: Blood pressure

Diagnostic Test: Peripheral arterial tonometry

Diagnostic Test: Anthropometry

Other: Questionnaire

Diagnostic Test: Blood sample

Study type

Interventional

Funder types

Other

Identifiers

NCT04181398

Palomino

Details and patient eligibility

About

Eligible candidates will be recruited within the children with overweight and obesity having a metabolic risk evaluation before treatment in the period 2006 and 2010 at the pediatric clinic of the UZ Brussel In total 60 participants will be investigated. Firstly, 30 participating patients with initially elevated hsCRP will be selected at random ( following the date of their initial investigation) and afterwards matched for age, BMI z-score, and blood pressure with the same number of patients without initially elevated hCRP values

Data will be collected as follows:

questionnaires
clinical examination/ anthropometry
blood sample (hsCRP)
peripheral arterial tonometry (endoPAT)

Full description

Obesity and overweight have become an important health burden in children and adolescents, with 19% of all children between 5 and 18 years being either obese or overweight in Belgium. Obesity and especially visceral adiposity early in life may contribute to the development of cardiovascular disease at older age, as it shows tracking into adulthood and is be associated with cardiovascular risk factors such as dyslipidemia, insulin resistance, arterial hypertension and low grade inflammation, in a variable percentage.

Low grade inflammation, as assessed by hSCRP, was found to be present in 20.6 % and 19.8 % of overweight children and adolescents. In adults, hSCRP levels between 1 and 3 mg/L and above 3 mg/L are considered coronary disease risk factors.

Endothelial dysfunction, know to precede the formation of atherosclerotic plaque, can be assessed in a non-invasive manner in children by peripheral artery tonometry. Only few studies have been performed in obese children with this bed-side technique, showing either normal of a disturbed function, reflected by a lower reactive hyperemia index. The association with low grade inflammation however was assessed in only one study. The investigators hypothesize that in adolescents and young adults with a history of childhood obesity a more disturbed endothelial function will be present in those with and /or current elevated hSCRP value.

Enrollment

20 patients

Sex

All

Ages

12 to 21 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age 12-21 years at the moment of evaluation
BMI > 1.3 Standard Deviation Score at the initial evaluation
Hs-CRP available at initial evaluation

Exclusion criteria

Acute of chronic Infection at the time of the study visit
Be or have been a smoker of tabacco

Trial design

Primary purpose

Screening

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

20 participants in 2 patient groups

Baseline high hs-CRP

Experimental group

Description:

Anthropometry: * Actual Height and weight * Calculated BMI from measured weight and height. * Pubertal development (Tanner stage) * Waist circumference * Skin fold measurement (Triceps and Subscapular) * Waist-to-height ratio. Blood pressure (mean of 3 measurements) Peripheral arterial tonometry Questionnaire Blood sample (hsCRP)

Treatment:

Diagnostic Test: Blood sample

Other: Questionnaire

Diagnostic Test: Anthropometry

Diagnostic Test: Peripheral arterial tonometry

Diagnostic Test: Blood pressure

Baseline low hs-CRP

Experimental group

Description:

Treatment:

Diagnostic Test: Blood sample

Other: Questionnaire