Low Intensity Training Combined With KAATSU on Muscle Vasodilatation and Arterial Stiffness in the Elderly Population

Hospital Israelita Albert Einstein

Status: Completed

Conditions: Frail Elderly Syndrome

Treatments: Procedure: Speed gait test; Other: Anthropometric Assessment; Diagnostic Test: Quality of Life EuroQol-5 Domain; Device: Isometric handgrip exercise protocol; Procedure: 1RM Test; Device: Measurement of Arterial Stiffness - Pulse Wave Analysis and Velocity; Device: Vasodilatory capacity; Device: Basal blood flow and vasodilatory capacity - Flow mediated dilation (FMD); Device: Venous occlusion plethysmography protocol

Study type: Interventional

Funder types: Other

Identifiers

NCT03272737

2016/07993-3

Details and patient eligibility

About

The purpose of the present study is to evaluate the acute and chronic effect of low intensity strength training with or without moderate blood flow restriction on muscle vasodilation and arterial stiffness in elders with low gait speed. In addition, the responses of prothrombotic factors in blood coagulation, the impact on heart rate and arterial pressure will be assessed.

Full description

The investigators propose a study of 26 sedentary elders with low speed gait, supervised by the Hospital Israelita Albert Einstein - Vila Mariana ambulatory. This will be an open clinical trial, prospective, single center, randomized and controlled study. It will be divided into two parts: acute and chronic phases. After signing an informed consent, the participants will be separated in two groups:

Group 1. Resistance exercise with low intensity combined with partial blood flow restriction Group 2. Conventional resistance exercise with low intensity

All of participants will be submitted to interventions tests before and after the period of training which are:

1. Laboratory Tests: Blood tests
2. Plethysmography
3. Handgrip
4. Quality of life questionaire
5. FMD tests
6. Vasodilation capacity

Enrollment: 26 patients

Sex: All

Ages: 60 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Elderly people aged 60 to 85 years, with walking speed <0.8m / s (Guralnik, 1994).

Exclusion criteria

• Elderly patients with uncontrolled diabetes mellitus or peripheral neuropathy;
• Symptomatic peripheral obstructive arterial disease or brachial ankle index <0.9;
• Uncontrolled arterial hypertension (BP> 160 / 100mmHg);
• Uncontrolled dyslipidemia (total colostrum> 220mg / dL);
• Infectious with less than 1 month;
• Osteoarticular or neurological problems that prevent training;
• History of anemia, cerebrovascular disease, myocardial infarction in the last 6 months;
• Pior deep venous thrombosis;
• Use of oral anticoagulant;
• Smoking <6 months;
• Use of antiplatelet agents and anticoagulants;
• Cognitive dysfunctions: Mini-mental <24. (Brucki, 2003).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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26 participants in 2 patient groups

Traditional strength exercise

Active Comparator group

Description:

This group will be carried out to knee extension exercise without blood flow restriction. Interventions: * Plethysmography; * Protocols of isometric exercise; * Pulse wave Velocity (PWV); * Flow-mediated dilatation (FMD); * Arterial pressure and blood pressure; * Quality of life (Euro Qol); * 1RM test * Speed gait test * Anthropometric Assessment

Treatment:

Diagnostic Test: Quality of Life EuroQol-5 Domain

Device: Isometric handgrip exercise protocol

Procedure: Speed gait test

Other: Anthropometric Assessment

Device: Basal blood flow and vasodilatory capacity - Flow mediated dilation (FMD)

Device: Venous occlusion plethysmography protocol

Device: Vasodilatory capacity

Procedure: 1RM Test

Device: Measurement of Arterial Stiffness - Pulse Wave Analysis and Velocity

Strength exercise with KAATSU

Active Comparator group

Description:

This group will be carried out to knee extension exercise with partial blood flow restriction. Interventions: * Plethysmography; * Protocols of isometric exercise; * Pulse wave Velocity (PWV); * Flow-mediated dilatation (FMD); * Arterial pressure and blood pressure; * Quality of life (Euro Qol); * 1RM test * Speed gait test * Anthropometric Assessment

Treatment:

Diagnostic Test: Quality of Life EuroQol-5 Domain

Device: Isometric handgrip exercise protocol

Procedure: Speed gait test

Other: Anthropometric Assessment

Device: Basal blood flow and vasodilatory capacity - Flow mediated dilation (FMD)

Device: Venous occlusion plethysmography protocol

Device: Vasodilatory capacity

Procedure: 1RM Test

Device: Measurement of Arterial Stiffness - Pulse Wave Analysis and Velocity