Low-Salt Diet Effect on Th17-Mediated Inflammation and Vascular Reactivity in Psoriasis

Josip Juraj Strossmayer University of Osijek

Status

Enrolling

Conditions

Psoriasis Vulgaris

Treatments

Other: Low-Salt Diet

Study type

Interventional

Funder types

Other

Identifiers

NCT05892640

215861462341

Details and patient eligibility

About

Psoriasis presents an independent cardiovascular risk factor characterized by chronic low-grade systemic inflammation and oxidative stress which altogether might lead to endothelial dysfunction. It has been reported that increased oxidative stress has a pivotal role in high dietary sodium-induced endothelial dysfunction. Previous studies on sodium accumulation in psoriatic skin lesions and the sodium-induced augmentation in Th17 immune response, raise the question on the complex interplay between sodium and psoriasis, especially in the context of cardiovascular morbidity.

This study aimed to investigate the effect of a 2-week low-salt diet on endothelium-dependent and endothelium-independent cutaneous microvascular vasodilation and Th17-Mediated Inflammation in patients with psoriasis vulgaris.

Enrollment

50 estimated patients

Sex

All

Ages

18 to 69 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patients with diagnosed psoriasis vulgaris
subjects do not use topical corticosteroid therapy for at least 2 weeks before inclusion in the study and 2 weeks during the study
subjects do not use systemic or biological therapy for at least 3 months before and 2 weeks during the study.

Exclusion criteria

age < 18 years
existence of other immune-mediated diseases (with the exception of autoimmune thyroid diseases and psoriatic arthritis - people with these comorbidities can be included)
malignant diseases
current infectious diseases and allergic reactions within 6 weeks before the start of the study