Low Tidal Volume for Lung Protection During Anesthesia of Laparoscopic Surgery in Trendlenburg Position (lapVent)

AlRefaey Kandeel

Status: Unknown

Conditions: Intraoperative Mechanical Ventilation

Treatments: Device: mechanical ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT02553057

DrSamah

Details and patient eligibility

About

Mechanical ventilation of patients undergoing laparoscopic surgery may induce lung injury. Since lung protective ventilation has been recommended during anesthesia to prevent ongoing lung injury, so in our study the investigators will compare three different lung protective strategies regarding their lung protective effect measured by the incidence of postoperative pulmonary complications, perioperative oxygenation and postoperative inflammatory mediator release.

Enrollment: 90 estimated patients

Sex: All

Ages: 20 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• all patients undergoing laparoscopic colorectal or gynaecologic surgery with expected time more than two hours

Exclusion criteria

• refusal, preoperative pulmonary disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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90 participants in 3 patient groups

Group 1

Active Comparator group

Description:

mechanical ventilation with Tidal volume 4 ml/kg and PEEP 8-10 cm H2o

Treatment:

Device: mechanical ventilation

Group2

Active Comparator group

Description:

mechanical ventilation with Tidal volume 6 ml/kg and PEEP 8-10 cm H2o

Treatment:

Device: mechanical ventilation

Group 3

Active Comparator group

Description:

mechanical ventilation with Tidal volume 8 ml/kg and PEEP 8-10 cm H2o

Treatment:

Device: mechanical ventilation