Low Tube Voltage Computed Tomographic (CT) Urography Using Low Concentration Iodine Contrast Agent

Seoul National University

Status: Unknown

Conditions: Exposure to Medical Diagnostic Radiation

Treatments: Radiation: Computed tomographic urography

Study type: Interventional

Funder types: Other

Identifiers

NCT01855204

SeoulNUH-rad

Details and patient eligibility

About

Computed Tomographic (CT) urography is the best imaging modality to evaluate obstructing lesions of urinary tract such as urinary stone, tumor and inflammatory lesion. The purpose of our study is to compare images of CT urography performed by low voltage and low concentrated iodine CT contrast with them of conventional CT urography.

Full description

Computed Tomographic (CT) urography is the best imaging modality to evaluate obstructing lesions of urinary tract such as urinary stone, tumor and inflammatory lesion. It is needed that CT urography should have the high contrast between target lesion described as filling defect and adjacent contrast filled urinary tract. For the implementation of high contras, conventional CT urography has been performed with higher voltage and higher concentrated CT contrast than another CT protocols. The higher voltage results in the more radiation exposure. And the intravenous injection of higher concentrated CT contrast results in the increase of the prevalence of contrast induced nephrotoxicity.

The purpose of our study is to compare images of CT urography performed by low voltage and low concentrated iodine CT contrast with them of conventional CT urography.

Enrollment: 64 estimated patients

Sex: All

Ages: 20 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients to perform Computed Tomographic (CT) urography
• Patients without diminish of renal function (serum creatinine: more than 1.4 mg/dl & glomerular filtration rate: more than 34 mL/min/1.73 m2)

Exclusion criteria

• patients to have operations and/or injuries of urinary system
• patients to have the histories of anaphylaxis or allergic reaction about intravenous iodine contrast material

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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64 participants in 2 patient groups

Conventional

Active Comparator group

Description:

Computed tomographic urography was done with conventional protocols.

Treatment:

Radiation: Computed tomographic urography

Reduced

Experimental group

Description:

Computed tomographic urography was done with the protocols of low voltage and low iodine concentration.

Treatment:

Radiation: Computed tomographic urography