Low Versus High Load Training and Parkinson's Disease

University of Miami

Status: Enrolling

Conditions: Activity, Motor

Treatments: Behavioral: Low-Load Resistance Training; Behavioral: High-Load Resistance Training

Study type: Interventional

Funder types: Other

Identifiers

NCT07378813

20251268

Details and patient eligibility

About

This study will compare the effects of high-load resistance training to low-load resistance training, on measures of muscle strength and power and tests of daily performance in older adults with Parkinson's disease.

Enrollment: 60 estimated patients

Sex: All

Ages: 50 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Parkinson's Disease Hoehn & Yahr Stages 1-3
• Able to walk 50m unassisted
• Able to understand and communicate in English
• A Montreal Cognitive Assessment (MoCA) score above 18

Exclusion criteria

• Uncontrolled cardiovascular or other neuromuscular disease that prevent participation in a training program
• Any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, or other serious concomitant medical illness
• Unresolved injury or surgery to the upper or lower limbs that prevents weight training.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

Low-Load Resistance Training

Active Comparator group

Description:

Participants will receive low-load resistance training, twice per week for at least 24 sessions for up to 12 weeks.

Treatment:

Behavioral: Low-Load Resistance Training

High-Load Resistance Training

Active Comparator group

Description:

Participants will receive high-load resistance training, twice per week for at least 24 sessions for up to 12 weeks.

Treatment:

Behavioral: High-Load Resistance Training