LRRK2 G2385R Leucocyte and Urine Biomarker Study

University of Malaya

Status: Unknown

Conditions: Parkinson Disease

Treatments: Other: This is a non-interventional study

Study type: Observational

Funder types: Other

Identifiers

NCT04436848

UMG2385R

Details and patient eligibility

About

Given the emerging evidence on LRRK2-related biomarkers, this project will focus on identifying leucocyte and urine biomarkers that are altered by the LRRK2 G2385R variant, and investigating the effects of LRRK2 kinase inhibitor (MLi-2) on these biomarkers, using immunoblotting and mass spectrometry.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosis of Parkinson's disease assigned by a movement disorder specialist according to clinical diagnostic criteria
• Age above 18 year-old
• Provision of a written informed consent

Exclusion criteria

• Physical or mental incapacity to complete study protocol

Trial design

150 participants in 3 patient groups

PD patients positive for LRRK2 G2385R

Treatment:

Other: This is a non-interventional study

PD patients negative for LRRK2 G2385R

Treatment:

Other: This is a non-interventional study

Non-PD controls negative for LRRK2 G2385R

Treatment:

Other: This is a non-interventional study