Lung Cancer Risk and Early Detection in Firefighters

Mass General Brigham

Status: Completed

Conditions: Lung Diseases; Lung Cancer

Treatments: Diagnostic Test: Low Dose CT

Study type: Interventional

Funder types: Other

Identifiers

NCT04614129

2020P002693

Details and patient eligibility

About

This study will evaluate whether LDCT findings differ between firefighters and non-fighters, the relationship between occupational exposures and LDCT findings, and whether a proteomics assay can further risk-stratify screen-detected nodules among a study population of 850 current and retired firefighters and 1,120 matched controls.

Enrollment: 734 patients

Sex: All

Ages: 40 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 40-80 years of age or with 10 years of firefighting experience
• Current or retired firefighters
• No personal history of lung cancer
• Willing and able to receive LDCT screening at MGH or who have been screened via LDCT within the past year at MGH or another institution, and are willing to release their images to the study

Exclusion criteria

• Any active cancer (undergoing treatment or diagnosed within the past 5 years)

Trial design

Primary purpose: Screening

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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734 participants in 1 patient group

Low-Dose CT

Experimental group

Description:

Low Dose CT Scan of the Chest

Treatment:

Diagnostic Test: Low Dose CT