Lung Cancer Screening Eligibility Assessment

Abramson Cancer Center at Penn Medicine

Status: Completed

Conditions: Lung Cancer

Treatments: Behavioral: Framed Introductory Message A; Behavioral: Framed Tobacco Use Message B; Behavioral: Framed Tobacco Use Message A; Behavioral: Financial Incentive; Behavioral: Framed Introductory Message C; Behavioral: Framed Introductory Message B

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT06133816

853337 (Other Identifier)

UPCC 16523

P50CA271338-02 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The primary purpose of this study evaluate if different messaging impacts response rates to a brief survey (i.e., the simplified eligibility tool) that is designed to estimate pack-year eligibility for lung cancer screening (LCS). This will help inform the best way to increase response rates to the tool in future intervention studies designed to increase LCS, and expand upon survey methodology in general.

Full description

Despite growing evidence that lung cancer screening (LCS) reduces lung cancer-specific mortality, LCS across the United States is remarkably low. This is due in part to challenges with identifying adults who meet eligibility criteria for lifetime smoking intensity (i.e., 20 pack-years or greater), which is often missing from the electronic medical record. We have developed a simplified eligibility tool that has shown accuracy in estimating pack-years. But given the potential for low response rates, there is a great need to identify effective strategies to increasing response rates equitably prior to using it in practice or in future studies. The primary purpose of this study evaluate if different messaging impacts response rates to a brief survey (i.e., the simplified eligibility tool) that is designed to estimate pack-year eligibility for lung cancer screening (LCS). This will help to identify the best way to increase response rates to the tool in future intervention studies designed to increase LCS, and expand upon survey methodology in general.

Enrollment: 6,125 patients

Sex: All

Ages: 50 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. meet age eligibility (50-80 years old) for LCS based on 2021 USPSTF guidelines; and
2. have completed at least one primary care visit at Penn Medicine in 2020-2025

Exclusion criteria

1. have a documented history of lung cancer;
2. have a documented history of completing LCS at Penn Medicine;
3. are listed as not wanting to be contacted or solicited for research; or
4. do not otherwise meet inclusion criteria.

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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6,125 participants in 12 patient groups

Arm 1 (Introductory Message A + Tobacco Use Message A + Incentive)

Experimental group

Description:

Participants will receive two framed messages (AA) plus an incentive

Treatment:

Behavioral: Financial Incentive

Behavioral: Framed Tobacco Use Message A

Behavioral: Framed Introductory Message A

Arm 2 (Introductory Message A + Tobacco Use Message A)

Experimental group

Description:

Participants will receive two framed messages (AA)

Treatment:

Behavioral: Framed Tobacco Use Message A

Behavioral: Framed Introductory Message A

Arm 3 (Introductory Message A + Tobacco Use Message B + Incentive)

Experimental group

Description:

Participants will receive two framed messages (AB) plus an incentive

Treatment:

Behavioral: Financial Incentive

Behavioral: Framed Tobacco Use Message B

Behavioral: Framed Introductory Message A

Arm 4 (Introductory Message A + Tobacco Use Message B)

Experimental group

Description:

Participants will receive two framed messages (AB)

Treatment:

Behavioral: Framed Tobacco Use Message B

Behavioral: Framed Introductory Message A

Arm 5 (Introductory Message B + Tobacco Use Message A + Incentive)

Experimental group

Description:

Participants will receive two framed messages (BA) plus an incentive

Treatment:

Behavioral: Financial Incentive

Behavioral: Framed Introductory Message B

Behavioral: Framed Tobacco Use Message A

Arm 6 (Introductory Message B + Tobacco Use Message A)

Experimental group

Description:

Participants will receive two framed messages (BA)

Treatment:

Behavioral: Framed Introductory Message B

Behavioral: Framed Tobacco Use Message A

Arm 7 (Introductory Message B + Tobacco Use Message B + Incentive)

Experimental group

Description:

Participants will receive two framed messages (BB) plus an incentive

Treatment:

Behavioral: Financial Incentive

Behavioral: Framed Introductory Message B

Behavioral: Framed Tobacco Use Message B

Arm 8 (Introductory Message B + Tobacco Use Message B)

Experimental group

Description:

Participants will receive two framed messages (BB)

Treatment:

Behavioral: Framed Introductory Message B

Behavioral: Framed Tobacco Use Message B

Arm 9 (Introductory Message C + Tobacco Use Message A + Incentive)

Experimental group

Description:

Participants will receive two framed messages (CA) plus an incentive

Treatment:

Behavioral: Financial Incentive

Behavioral: Framed Introductory Message C

Behavioral: Framed Tobacco Use Message A

Arm 10 (Introductory Message C + Tobacco Use Message A)

Experimental group

Description:

Participants will receive two framed message (CA)

Treatment:

Behavioral: Framed Introductory Message C

Behavioral: Framed Tobacco Use Message A

Arm 11 (Introductory Message C + Tobacco Use Message B + Incentive)

Experimental group

Description:

Participants will receive two framed messages (CB) plus an incentive

Treatment:

Behavioral: Financial Incentive

Behavioral: Framed Introductory Message C

Behavioral: Framed Tobacco Use Message B

Arm 12 (Introductory Message C + Tobacco Use Message B)

Experimental group

Description:

Participants will receive two framed messages (CB)

Treatment:

Behavioral: Framed Introductory Message C

Behavioral: Framed Tobacco Use Message B