Lung Cancer Screening in High-risk Black Individuals

Mass General Brigham

Status: Enrolling

Conditions: Lung Cancer; Lung Carcinoma

Treatments: Procedure: Low-dose Computed Tomography

Study type: Interventional

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT05898594

1R18HS029430-01 (Other Identifier)

22-382

Details and patient eligibility

About

The goal of this research study is to study U.S. Black individuals with a history of smoking to examine the feasibility, acceptability, and performance of low-dose computed tomography (LDCT) screening among this population.

The name of the intervention used in this research study is:

Low-dose computed tomography (radiologic scan) chest scan

Full description

The goal of this single-arm pilot research study is to evaluate the feasibility and acceptability of low-dose computed tomography (LDCT) screening for lung cancer among U.S. Black individuals with a history of smoking.

LDCT screening is currently the only recommended way to screen for lung cancer among high-risk individuals. However, many Black individuals at high-risk for lunch cancer are currently ineligible for lung cancer screening.

Study procedures include screening for eligibility, completion of questionnaires, and a LDCT screening test.

Participation in this study is expected to last up to 3 months.

It is expected about 900 people will participate in this study.

Enrollment: 900 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Self-identified Black individual.
• Have a self-reported history of smoking. No restriction will be placed on the number of smoking pack years participants must have nor the number of years former smokers must have quit smoking.
• Aged >= 50 years.

Exclusion criteria

• Individuals with a history of lung cancer.
• Individuals with symptoms suggestive of lung cancer. We will evaluate whether individuals have symptoms suggestive of lung cancer by administering an online screening questionnaire, which will ask whether they have experienced shortness of breath, whether they become easily winded, and whether they have had a chronic cough within the last 12 weeks that has not improved. Individuals who select that they have any one of these symptoms will be advised to follow up with their primary doctor and will not be eligible to participate in the study.
• Individuals with pneumonia or acute respiratory infection within 12 weeks prior to enrollment that was treated with antibiotics.

Trial design

Primary purpose: Screening

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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900 participants in 1 patient group

Screening: Low-Dose Computed Tomography Screening

Experimental group

Description:

Participants will undergo study procedures as outlined: * Complete questionnaires pre- and post- low-dose computed tomography (LDCT) test. * Visit Massachusetts General Hospital facility for a LDCT screening test.

Treatment:

Procedure: Low-dose Computed Tomography