Lung Function of Asthmatic Children by Nebulized MgSO4

Chongqing Medical University

Status: Completed

Conditions: Asthma

Treatments: Drug: Magnesium Sulfate & albuterol; Drug: albuterol; Drug: magnesium

Study type: Interventional

Funder types: Other

Identifiers

NCT01799109

MS-2012CQ

Details and patient eligibility

About

Asthma is a common chronic respiratory illness which results in frequent wheezing, cough,reduced quality of life. Standard treatment for asthma attack includes oxygen therapy, β2-agonists (e.g. albuterol) and inhaled anticholinergics and corticosteroids. Although inhaled short-acting β2-agonists (SAB) is the initial choice to control acute asthma exacerbation, there are still some asthmatic children unresponsive to this management. The Global Initiative in National Asthma (GINA) does not recommend intravenous magnesium sulfate (MgSO4) for routine use in asthma exacerbation especially in young children. But intravenous MgSO4 can reduce hospital admission rates in certain patients due to several effects e.g relaxation of smooth muscle,blocking acetylcholine. In addition,adding MgSO4 to nebulized SAB provides greater benefit in severe asthma exacerbation.

Enrollment: 90 patients

Sex: All

Ages: 4 to 10 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• asthmatic children with controlled clinical manifestation

Exclusion criteria

• fever
• history of chronic disease like bronchopulmonary dysplasia or cystic fibrosis
• allergic to acetylcholine, albuterol or magnesium
• use any bronchodilator agents before the Clinic day

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

---

90 participants in 3 patient groups

nebulization ms and albuterol

Experimental group

Description:

magnesium sulfate 150mg \& albuterol 2.5mg nebulized with 5-6L/min of oxygen and consisted about 5 min,which used only once

Treatment:

Drug: Magnesium Sulfate & albuterol

nebulized albuterol

Active Comparator group

Description:

albuterol 2.5mg nebulized with 5-6L/min of oxygen and consisted about 5 min,which used only once

Treatment:

Drug: albuterol

nebulized ms

Experimental group

Description:

magnesium sulfate 150mg nebulized with 5-6L/min of oxygen and consisted about 5 min,which used only once

Treatment:

Drug: magnesium