Lung Health of Early COPD: a Multi-center Cohort Study (LHEC)

Ting YANG

Status: Enrolling

Conditions: COPD

Treatments: Behavioral: smoking

Study type: Observational

Funder types: Other

Identifiers

NCT05466396

LHEC

Details and patient eligibility

About

This is a multi-center, prospective, cohort study in early COPD patients. This study aims to elucidate the lung function decline and its association with smoking and other risk factors. Other biomarkers and image markers from chest CT scan are also analyzed to investigate the lung function in early COPD patients.

Enrollment: 1,550 estimated patients

Sex: All

Ages: 35 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Gender: male or female
2. Age: 35-75 years old
3. post-bronchodilator spirometry: FEV1/FVC < 0.8 and FEV1%pred ≥80%

Exclusion criteria

1. Other diseases may affect lung function, like lung cancer, bronchiectasis, interstitial lung disease or chest surgery.
2. BMI > 35 kg/m2
3. Dementia or other severe neurological disease
4. Pregnancy
5. Conditions that contraindicated lung function test

Trial design

1,550 participants in 5 patient groups

Smokers with Pre-COPD

Description:

Smoking history ≥ 10 pack-years 0.7≤ FEV1/FVC\<0.8 and FEV1%pred ≥ 80% (post-bronchodilator)

Treatment:

Behavioral: smoking

Smokers with Mild-COPD

Description:

Smoking history ≥ 10 pack-years FEV1/FVC\<0.7 and FEV1%pred ≥ 80% (post-bronchodilator)

Treatment:

Behavioral: smoking

Non-Smokers with Pre-COPD

Description:

Smoking history \< 10 pack-years or never-smokers 0.7≤ FEV1/FVC\<0.8 and FEV1%pred ≥ 80% (post-bronchodilator)

Non-Smokers with Mild-COPD

Description:

Smoking history \< 10 pack-years or never-smokers FEV1/FVC\<0.7 and FEV1%pred ≥ 80% (post-bronchodilator)

Healthy Controls

Description:

Healthy volunteers without smoking history FEV1/FVC ≥ 0.8 and FEV1%pred ≥ 80% (post-bronchodilator)