Lung Open Ventilation to Decrease Mortality in the Acute Respiratory Distress Syndrome (LOVS)

Hamilton Health Sciences (HHS)

Status and phase

Completed

Phase 3

Conditions

Acute Respiratory Distress Syndrome

Treatments

Procedure: Control Ventilation Strategy

Study type

Interventional

Funder types

Other

Identifiers

NCT00182195

38141-1

Details and patient eligibility

About

A multinational, randomized trial comparing two lung protecting strategies of respiratory life support among critically ill patients with severe lung injury.

Full description

To compare an innovative Lung Open Ventilation strategy with a proven low tidal volume strategy, hypothesizing that the Lung Open Ventilation strategy may reduce mortality, other organ dysfunction, and the duration of mechanical ventilation, intensive care, and hospital stay.

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Invasive mechanical ventilation
Acute respiratory insufficiency (within past 28 days)
Bilateral infiltrates on frontal chest radiograph
Hypoxemia, defined as PaO2/FiO2<=250

Exclusion criteria

Primary cause of respiratory failure is cardiac
Anticipated duration of mechanical ventilation < 48 hours
Inability to wean other experimental ventilation strategies
Severe chronic respiratory disease
Neuromuscular disease that will prolong mechanical ventilation
Conditions where hypercapnia-induced intracranial hypertension should be avoided
Morbid obesity (> 1Kg per cm body weight)
Pregnancy
Very unlikely to survive and lack of commitment to life support Underlying irreversible condition with 6 month mortality >= 50%
Greater than 48 hours elapsed since first eligible
Current participation in competing trial
Lack of physician, patient or proxy consent