Lung Overdistension and Abdominal Pressure Rise (LOVE BEER)

University of Padova

Status: Enrolling

Conditions: Respiratory Failure; Respiratory Distress Syndrome, Adult

Treatments: Procedure: Application of abdominal weight

Study type: Interventional

Funder types: Other

Identifiers

NCT06174636

AOP2978

Details and patient eligibility

About

The goal of this pilot interventional no-profit study is to evaluate airway pressure, esophageal pressure and variations in lung volume distribution with EIT in mechanically ventilated patients admitted to our UTI with respiratory failure after the application of an abdominal weight and resulting increase of intra-abdominal pressure.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Invasive mechanical ventilation in acute respiratory failure (PaO2/FiO2 <300 mmHg)
• Need of PEEP trial
• Need of urinary catheter (used to measure IAP)

Exclusion criteria

• Contraindication to EIT use
• Pacemaker or other metal device in thoracic region
• Contraindication to abdominal weight placement
• Surgical or traumatic incision on the abdomen
• Severe abdominal hypertension
• Esophageal diseases that counterindicate naso-gastric tube placement
• Severe hemodynamic instability (norepinephrine > 0.1 mcg/kg/min; dobutamine or dopamine > 5 mcg/kg/min; epinephrine every dosage)
• Severe obesity (BMI > 35 kg/m2)
• Need of > 7 kg weight to reach 5 mmHg IAP increase

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Abdominal Pressure Rise

Experimental group

Description:

Application of an abdominal weight and record of respiratory mechanics data, intra-abdominal pressure variation, Electrical Impedance Tomography data

Treatment:

Procedure: Application of abdominal weight