Lung Perfusion With Oxygenated Blood During Aortic Clamping (PulPer-001-Sch)

Johann Wolfgang Goethe University Hospital

Status: Completed

Conditions: Postoperative Pulmonary Dysfunction

Treatments: Procedure: no lung perfusion; Procedure: lung perfusion

Study type: Interventional

Funder types: Other

Identifiers

NCT01186510

PulPer-001-Sch

Details and patient eligibility

About

Pulmonary dysfunction presumably linked to an inflammatory response is frequent after cardiac operations using cardiopulmonary bypass (CPB) and pulmonary hypoperfusion.

Aim of the study: To evaluate the protective effect of continuous pulmonary perfusion with oxygenated blood during aortic crossclamping on the inflammatory response.

Enrollment: 50 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-80 ys
• Cardiopulmonary bypass procedure
• FEV1 <80%
• COPD >II

Exclusion criteria

• Emergency cases

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

50 participants in 2 patient groups

Lung perfusion

Experimental group

Treatment:

Procedure: lung perfusion

no lung perfusion

Active Comparator group

Treatment:

Procedure: no lung perfusion