Lung Protection Strategy in Open Heart Surgery: Which Tidal Volume is Better 8ml/kg or 6ml/kg

Kocaeli University

Status: Completed

Conditions: Ventilator Adverse Event; Ventilator-Induced Lung Injury; Lung Injury, Acute

Treatments: Device: Mechanical ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT03651817

KÜ GOKAEK 2018/68

Details and patient eligibility

About

Respiratory complications range from 8% to 79% of the frequency after open heart surgery where the patient is on-pump operated by cardiopulmonary machine. There were many changes in physiology due to anesthesia and cardiac surgery which cause volume and barotrauma complications with mechanical ventilation. These complications increase cost by prolonging morbidity and morbidity as well as hospital stay. Intraoperative and postoperative mechanical ventilation strategies can prevent these complications. CPB stimulates the systemic inflammatory response to the secretion of neutrophil, endotoxin and proinflammatory cytokines in the complex, increasing the permeability of the capillaries. Although coronary artery bypass graft surgery (CABG) is associated with a 0.4% to 2.0% acute respiratory distress syndrome (ARDS), mortality is quite high. Lung-protective ventilation strategies commonly used for prevention of ARDS. Ferrando et al. have proposed pulmonary ventilation with a tidal volume (TV) of less than 10 mL / kg as a pulmonary intraoperative protective ventilation strategy. Investigators aimed to compare oxygenation and ventilation parameters with respiratory mechanics in patients who underwent open heart surgery and were ventilated with 6 ml / kg tidal volume and 8 ml / kg TV, which were recommended as lung protective ventilation strategies during anesthesia.

Enrollment: 32 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Undergoing Cardiopulmonary bypass

Exclusion criteria

• Severe COPD
• Chronic Anemia
• Active Smoker
• Chronic kidney Disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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32 participants in 2 patient groups

6ml/kg volume

Active Comparator group

Description:

Patients ventilation will provided with a tidal volume of 6ml/kg

Treatment:

Device: Mechanical ventilation

8ml/kg volume

Active Comparator group

Description:

Patients ventilation will provided with a tidal volume of 8ml/kg

Treatment:

Device: Mechanical ventilation