Lung Protective Ventilation During Pulmonary Lobectomy in Children

Seoul National University

Status: Completed

Conditions: Pulmonary Complication

Treatments: Procedure: Conventional ventilation; Procedure: lung protective ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT02680925

H1511-124-725

Details and patient eligibility

About

The investigator will evaluate the influence of lung protective ventilation on postoperative clinical outcome in pediatric patients. The hypothesis is that application of low tidal volume, intermittent alveolar recruitment and adequate positive end-expiratory pressure (PEEP) would be more beneficial than conventional ventilation in children.

Enrollment: 114 patients

Sex: All

Ages: Under 5 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children who are scheduled for lung lobectomy under general anesthesia
• ASA physical status I, II

Exclusion criteria

• History of airway or pulmonary interstitial disease
• Active URI
• Systemic inflammatory response disease
• cardiac disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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114 participants in 2 patient groups, including a placebo group

Conventional ventilation group

Placebo Comparator group

Description:

Mechanical ventilation is maintained with tidal volume (TV) of 10 ml/kg without PEEP during two-lung ventilation and TV of 8 ml/kg without PEEP during one-lung ventilation. Alveolar recruitment is performed 3 times; after intubation, before one-lung ventilation and after lung resection.

Treatment:

Procedure: Conventional ventilation

Lung protective ventilation group

Active Comparator group

Description:

Mechanical ventilation is maintained with tidal volume (TV) of 6 ml/kg with PEEP 6 cmH2O during two-lung ventilation and TV of 4 ml/kg PEEP 6 cmH2O during one-lung ventilation. Alveolar recruitment is performed 3 times; after intubation, before one-lung ventilation and after lung resection.

Treatment:

Procedure: lung protective ventilation