Lung Recruitment and Postoperative CPAP (LRvsCPAP)

Assiut University

Status and phase: Completed; Phase 2

Conditions: Anesthesia

Treatments: Device: Postoperative CPAP mask; Device: Engström Datex-Ohmeda ICU Ventilator

Study type: Interventional

Funder types: Other

Identifiers

NCT02502279

IRB00008718/ refer.34

Details and patient eligibility

About

General anesthesia lowers FRC thereby promoting airway closure and absorption atelectasis. Alveolar recruitment manoeuvers recruit collapsed alveoli, increase gas exchange, and improve arterial oxygenation.

Full description

General anesthesia lowers FRC thereby promoting airway closure and absorption atelectasis. Alveolar recruitment manoeuvers recruit collapsed alveoli, increase gas exchange, and improve arterial oxygenation. However, the effect of recruitment manoeuvre is short lasting and does not extend to the post operative period. Postoperative CPAP keeps the lung open and can improve oxygenation in the early postoperative period.

Enrollment: 60 patients

Sex: Male

Ages: 6 months to 6 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pediatric patients undergoing laparoscopic surgery for abdominal cryptorchidism.

Exclusion criteria

• Cardio-respiratory illness.
• Unsatisfactory preoperative peripheral arterial oxygen saturation.
• Unsatisfactory preoperative hemoglobin level.
• Neurological or psychiatric disease.
• Children with a BMI >95th percentile for age.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 3 patient groups

Control

No Intervention group

Description:

Engström Datex-Ohmeda ICU Ventilator: Pediatric patients under general anesthesia will be mechanically ventilated with the conventional ventilator parameters with 0 PEEP/CPAP.

Lung Recruitment- PEEP group

Active Comparator group

Description:

Engström Datex-Ohmeda ICU Ventilator: Pediatric patients under general anesthesia will be mechanically ventilated with the conventional ventilator parameters plus lung recruitment manoeuvre with peak inflation pressure 35 cmH2O for 15 seconds followed by PEEP until extubation delivered by the ventilator.

Treatment:

Device: Engström Datex-Ohmeda ICU Ventilator

Lung Recruitment- PEEP and CPAP group

Active Comparator group

Description:

Engström Datex-Ohmeda ICU Ventilator: Pediatric patients under general anesthesia will be mechanically ventilated with the conventional ventilator parameters plus 1. lung recruitment manoeuvre with peak inflation pressure 35 cmH2O for 15 seconds followed by PEEP until extubation delivered by the ventilator. 2. Postoperative CPAP mask immediately after extubation

Treatment:

Device: Postoperative CPAP mask

Device: Engström Datex-Ohmeda ICU Ventilator