Lung Recruitment Assessed by 2D/3D-EIT and R/I Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Enrolling

Conditions: Acute Respiratory Failure (ARF)

Treatments: Diagnostic Test: The lung recruitment potential assessed and PEEP titration by ventilator and 2D/3D EIT

Study type: Observational

Funder types: Other

Identifiers

NCT07379242

3D EIT-based PEEP & R/I ratio

Details and patient eligibility

About

The purpose of this observational study is to assess the differences and consistency in evaluating lung recruitment potential between the recruitment-to-inflation ratio (R/I ratio) and three-dimensional electrical impedance tomography (3D-EIT) and two-dimensional EIT (2D-EIT) in mechanically ventilated patients with acute respiratory failure. The main questions it aims to answer is:

Are the lung recruitment potentials predicted by 3D-EIT, 2D-EIT and the R/I ratio consistent? Participants will: Undergo a standardized PEEP titration protocol with synchronized EIT monitoring; Have R/I ratios measured at high and low PEEP levels.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Mechanically ventilated patients under sedation and analgesia with no spontaneous breathing.
• Oxygenation index < 300 mmHg.
• Patients who are clinically judged by the attending doctor to require the PEEP titration.

Exclusion criteria

• Aged under 18 years.
• Pregnancy.
• Contraindications for EIT examination (e.g. automatic implantable cardioverter defibrillator, implantable pumps, chest wounds limiting electrode belt placement, severe thoracic deformity, and others).
• No informed consent obtained.
• Hemodynamic instability with intolerance to high PEEP levels determined by the attending doctor.
• High-risk populations with pneumothorax, mediastinal emphysema, and other such conditions determined by the attending doctor.

Trial design

50 participants in 1 patient group

Mechanically ventilated patients with hypoxemia requiring clinical PEEP optimization

Description:

The study will enroll mechanically ventilated patients under sedation/analgesia without spontaneous breathing, exhibiting a oxygenation index (PaO₂/FiO₂ ratio) \<300 mmHg, and deemed clinically eligible for PEEP titration by attending physicians.

Treatment:

Diagnostic Test: The lung recruitment potential assessed and PEEP titration by ventilator and 2D/3D EIT