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Lung Recruitment Improves Right Ventricle Performance

H

Hospital Privado de Cordoba, Argentina

Status

Completed

Conditions

Atelectasis

Treatments

Procedure: Lung recruitment maneuver

Study type

Interventional

Funder types

Other

Identifiers

NCT02795208
HPrivadoCordoba

Details and patient eligibility

About

This study test whether a lung recruitment maneuver improves the right ventricle performance after cardiopulmonary bypass. Half of the patients received an standard protective ventilation and the other half the same ventilatory pattern after a lung recruitment maneuver.

Full description

Atelectasis is developed in 90% of anesthetized patients after surgery.

Protective ventilation with low tidal volumes and positive-end expiratory pressure (PEEP) promotes atelectasis with the potential right ventricle dysfunction induced by the increment in afterload (activation of the pulmonary hypoxic vasocontriction reflex).

Lung recruitment can improve the right ventricle performance caused by atelectasis because the pulmonary hypoxic vasocontriction reflex desapear in a normal aerated lungs.

Enrollment

40 patients

Sex

All

Ages

40 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • cardiovascular surgery with cardiopulmonary bypass.
  • Patients with a New York Heart Association (NYHA) class I-II,
  • Pre-operative left ventricular ejection fraction ≥ 50 %.
  • Euroscore ≤ 6.

Exclusion criteria

  • TEE contraindications.
  • Hemodynamically unstable
  • Needi for inotropic support

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

40 participants in 2 patient groups

Control group
No Intervention group
Description:
Patients received standard protective ventilation along the protocol.
Recruitment maneuver group
Experimental group
Description:
Patient received a lung recruitment maneuver after cardiopulmonary bypass. The recruitment maneuver consists in 10 breaths at 40/20 cmH2O of plateau pressure and PEEP, respectively. Then, the .ventilatory settings back to protective ventilation but adding 10 cmH2O of PEEP to keep the lungs open.
Treatment:
Procedure: Lung recruitment maneuver

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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