Lung Screen Uptake Trial (Lung-SCREEN)

University College London (UCL)

Status: Completed

Conditions: Lung Cancer

Treatments: Behavioral: Control invitation materials; Behavioral: Intervention invitation materials

Study type: Interventional

Funder types: Other

Identifiers

NCT02558101

15/0204

Details and patient eligibility

About

This study tests the impact of a novel invitation strategy on attendance rates to a pre-lung cancer screening lung health check appointment. Patients will be individually randomised (1:1) to receive either control invitation materials or intervention invitation materials. Those who attend will undergo a "lung health check" and be invited to a baseline screening scan if eligibility criteria are fulfilled.

Full description

Lung cancer screening using low dose computed tomography (LDCT) scans has been shown to reduce lung cancer-specific and all-cause mortality in a large United States (US) trial, and screening is now being carried out in the US. Studies have shown that participation rates are invariably low, particularly by current smokers and those from socioeconomically deprived backgrounds; groups within which high risk candidates are overrepresented.

In this study the investigators aim to improve informed participation in screening and reduce socioeconomic and smoking-related biases in participation. The investigators will identify individuals at high risk of lung cancer; specifically adults aged 60-75 who are current or recent former smokers. Eligible individuals will be invited by their General Practitioner to a "lung health check appointment" via one of two randomly allocated invitation strategies. The control materials will be similar to those used by UK screening programmes for other cancer types. The intervention materials have been designed to reduce barriers to participation among smokers from low socioeconomic status backgrounds.

Those that attend will have a lung cancer risk assessment, and if confirmed to be eligible, will undergo a baseline LDCT scan. Data will be collected with respect to demographics, risk and various clinical and radiological outcomes.

Enrollment: 1,997 patients

Sex: All

Ages: 60 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Recorded as a current smoker during the year 2010 or in subsequent years since then.

Exclusion criteria

• Active diagnosis of lung cancer or metastases
• CT thorax within the past year
• Inability to consent to study
• Palliative care register
• GPs alert to co-morbidity that contraindicates screening or treatment for lung cancer

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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1,997 participants in 2 patient groups

Control invitation materials

Active Comparator group

Description:

Invitation materials and strategy mimicking those of existing UK screening programmes for other cancer types

Treatment:

Behavioral: Control invitation materials

Intervention invitation materials

Experimental group

Description:

A targeted, stepped and low information burden invitation strategy and materials, specifically designed to improve uptake by reducing barriers to participation among smokers from socioeconomically deprived backgrounds.

Treatment:

Behavioral: Intervention invitation materials