Lung Tumor Protein Synthesis Rates in Lung Cancer Patients (LungMaas)

Maastricht University Medical Centre (MUMC)

Status: Enrolling

Conditions: Lung Cancer

Treatments: Other: There are no interventions in the present study

Study type: Observational

Funder types: Other

Identifiers

NCT05794529

METCZ20220060

Details and patient eligibility

About

The current study will recruit lung cancer patients to measure tissue protein synthesis rates of non-small cell lung carcinomas and healthy lung tissue. The protein synthesis rates of healthy lung tissue will be compared to lung tumor tissue to establish the remodeling characteristics of healthy versus cancerous lung tissues. We will also examine whether tissue protein synthesis rates of non-small cell lung carcinomas are associated with various tumor- (i.e., size, subclassification) and patient-derived (i.e., inflammation, lung function, smoking status, and smoking history) parameters.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Aged 18-65 years
2. Compos mentis
3. Diagnosed with lung cancer, with treatment requiring a thoracotomy or VATS lobectomy

Exclusion criteria

1. Neoadjuvant chemo- or radiotherapy in the past four weeks
2. Use of systemic steroids in the past four week
3. Insulin-dependent diabetes mellitus
4. Pregnancy

Trial design

30 participants in 1 patient group

Lung cancer patient

Description:

Lung cancer patients diagnosed a non-small cell lung carcinoma requiring resection surgery.

Treatment:

Other: There are no interventions in the present study