Lung Ultrasound for COVID-19 Initial Triage and Monitoring (QUICK)

Toulouse University Hospital

Status: Completed

Conditions: Lung Ultrasound; COVID-19; CT Scan; Triage; Acute Respiratory Failure

Treatments: Other: thoracic lung ultrasound

Study type: Observational

Funder types: Other

Identifiers

NCT04474236

2020-A01445-34 (Other Identifier)

RC31/20/0182

Details and patient eligibility

About

The QUICK study main aim is to assess the predictive value at Day 1, of a model built on lung ultrasound (LUS) and clinical data, both recorded at hospital admission of COVID-19 patients.

Full description

Initial triage assessment is the cornerstone of first-line medical management for COVID-19 patients. Only an accurate and fast evaluation of COVID-19 patients respiratory system integrity, can allow optimal treatment care and medical resources attribution. Despite its very large deployment, the use of thoracic Computed Tomography (CT scan) for COVID-19 patients severity assessment is currently debated. Actually CT-scan use in this setting: i) it is associated with risky in/out hospital patient's transport, both in terms of medical management of patient's critical conditions and risk of COVID-19 nosocomial transmission, ii) risks related to x-ray exposure iii) CT-scan is a snapshot of respiratory system integrity and does not provide data that might be used for patient's monitoring. LUS is a non-invasive, non-ionizing, fully bedside imaging tool. Investigators team has previously contributed to the development and validation of LUS for critically ill patient's management. To the extent of our knowledge, there is neither data regarding COVID-19 patient's LUS patterns, nor about the potential link between LUS data, patient's severity and outcome.

The investigators hypothesize that the combined use of LUS and clinical data (Q-SOFA score, SpiO2/FiO2) recorded at COVID-19 patients hospital admission, will allow to accurately predict short-term outcome. The investigators expect to predict at patient's hospital admission, the patient's clinical status at 24h: favorable (spontaneous ventilation with O2 < 6 l/min) or unfavorable (spontaneous ventilation with O2 > 6 l/min or under mechanical ventilation).

Enrollment: 25 patients

Sex: All

Ages: 17+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult (> 18 years).
• Proven COVID-19 (specific PCR from respiratory track sample)
• CT scan prescribed by physician in charge, independently of research.
• Patients consent (or surrogate decision maker's consent in case of need).

Exclusion criteria

• Reduction or cessation of active treatment.
• Patient under guardianship, tutelage measure or judicial protection
• Patient deprived of liberty by judicial order
• No French health insurance.
• Pregnancy or nursing woman.
• Enrolled in another trial evaluating thoracic imaging.

Trial design

25 participants in 1 patient group

COVID-19 patients

Description:

Adult (\> 18 years) with Proven COVID-19 (specific PCR from respiratory track sample)

Treatment:

Other: thoracic lung ultrasound