Lung Volume Perception and Impact of a Cognitive Task on Ventilation in Hypermobile Ehlers-Danlos Syndrome. (ProprioRespi)

Hakimi Adrien

Status: Completed

Conditions: Hypermobile Ehlers-Danlos Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT05000151

ProprioRespi

Details and patient eligibility

About

Patients with hypermobile Ehlers-Danlos syndrome have respiratory and proprioceptive disorders. The aim of this study is to explore whether there is an alteration in lung volume perception in patients with hEDS compared to healthy subjects, and whether a cognitive task can influence ventilation control differently in subjects with hEDS than in healthy subjects.

Enrollment: 38 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria (common):

• More than 18 years old
• Understanding French

Inclusion Criteria (hEDS Patients):

• hEDS diagnosis

Inclusion Criteria (healthy subjects):

• Age (±5 years), Gender and BMI (±2.5kg/m²) matching

Exclusion Criteria (common):

• Pregnancy

Exclusion Criteria (hEDS Patients):

• Respiratory comorbidity independent of hEDS
• Previous participation in a rehabilitation programme at the clinic

Exclusion Criteria (healthy subjects):

• Known respiratory or proprioceptive pathology
• Hypermobility (evaluated with the Beighton score)

Trial design

38 participants in 2 patient groups

Patients

Description:

Hypermobile Ehlers-Danlos patients (n=21)

Healthy subjects

Description:

Healthy subjects recruited from the clinic's staff (n=21) Age, Gender and BMI matched with hEDS patients