Lung Volume Recruitment for Lung Function and Cough Impairment in Multiple Sclerosis

Ottawa Hospital Research Institute

Status: Unknown

Conditions: Multiple Sclerosis

Treatments: Procedure: Lung volume recruitment

Study type: Interventional

Funder types: Other

Identifiers

NCT01891071

AA-HCLM-14-019 (Other Identifier)

20120570-01H (Other Identifier)

MS-LVR-01

Details and patient eligibility

About

Multiple sclerosis is a neurological disease that can affect lung function and cough efficacy. This pilot study will examine whether the lung volume recruitment technique can slow down the decline in lung function and cough.

Enrollment: 35 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• History of multiple sclerosis, diagnosed by a neurologist in accordance with the 2010 McDonald criteria

Exclusion criteria

• Concomitant parenchymal pulmonary disease or pleural disease
• Symptomatic cardiomyopathy
• Unable to perform pulmonary function testing or lung volume recruitment, due to comprehension or cooperation issues, physical inability such as bulbar or cerebellar dysfunction
• Contra-indication to pulmonary function testing or lung volume recruitment such as myocardial infarction, bleeding aortic aneurysm, intracranial hemorrhage within the previous month
• Known susceptibility to pneumothorax or pneumomediastinum
• Not competent to provide informed consent

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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35 participants in 2 patient groups

Lung volume recruitment

Experimental group

Description:

Lung volume recruitment twice daily for 9 months

Treatment:

Procedure: Lung volume recruitment

Standard care

No Intervention group

Description:

Standard care