LXRs, Cholesterol Metabolism and Uterine Dystocia

Centre Hospitalier Universitaire de Nīmes

Status

Terminated

Conditions

Uterine Inertia

Dystocia

Treatments

Biological: Whole blood sampling

Study type

Observational

Funder types

Other

Identifiers

NCT01107158

2009-A00968-49 (Other Identifier)

AOI/2009/KM-01

Details and patient eligibility

About

Despite the fact that a link between cholesterol and the myometrium has been clearly established, no study investigating aspects of cholesterol metabolism and uterine dystocia currently exists. This study is a pilot study whose aim is to test the hypothesis that an association between uterine dystocia and single-nucleotide polymorphisms (SNPs) in the genes coding for the LXRs.

Enrollment

58 patients

Sex

Female

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients undergoing C-section for a dystocia: 2 to 3 hours of stagnation in labor progress are observed (ie no increasing dilation, and uterine contractions less that 3-5 per 10 minutes) in spite of measures taken to overcome dystocia (oxytocin injection and artificial breaking of waters)
the child is alive
the child does not have apriori known malformations that could interfere with a vaginal birth
foetus in cephalic position
full term pregnancy (>= 37 weeks of amenorrhea)
single birth
patient has signed consent
patient is affiliated with a social security system

Exclusion criteria

vaginal birth
programmed C-section
C-section is chosen because the fetus has a cardia rhythm problem, and there is no stagnation in the labor process
multiple pregnancy
the child is in a breech position
premature birth (<37 weeks amenorrhea)
in utero fetal death
fetal malformation known before birth that could interfere with a vaginal birth
non french-speaking patient (impossible to correctly inform the patient)
patient under guardianship