Lymphangioleiomyomatosis, a Study on Cathepsin K (LAM-CAK)

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: Tuberous Sclerosis Complex; Lymphangioleiomyomatosis

Treatments: Other: urine sample; Other: 24h urine

Study type: Observational

Funder types: Other

Identifiers

NCT05323370

DR220020

Details and patient eligibility

About

This is a physiopathological case-control, non-interventional, monocentric study of adult patients with lymphangioleiomyomatosis. The controls are patients followed in neurology at the CHU of Tours for a tuberous sclerosis complex without lymphangioleiomyomatosis, the healthy volunteers are women with neither pulmonary nor renal pathology and recruited at the clinical investigation centre of the CHU of Tours.

Enrollment: 19 patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria for patients with lymphangioleiomyomatosis

• Age ≥ 18 years
• Female carrier of lymphangioleiomyomatosis according to ERS criteria

Inclusion criteria for healthy female volunteers

• Age ≥ 18 years
• Women with no history of lymphangioleiomyomatosis, pulmonary, renal or osteoporotic disease

Inclusion criteria for tuberous sclerosis complex patients without lymphangioleiomyomatosis

• Age ≥ 18 years
• Woman followed for tuberous sclerosis complex for whom a chest CT scan less than 3 years old does not objectify a pulmonary cyst. (= without lymphangioleiomyomatosis)

Non-inclusion criteria

• Woman under judicial protection
• Woman with a urinary tract infection within 15 days
• Person who objected to the data processing

Trial design

19 participants in 3 patient groups

Patientes with lymphangioleiomyomatosis

Description:

no intervention administered. Recruitment in pneumology department

Treatment:

Other: 24h urine

Other: urine sample

Patientes with tuberous sclerosis complex without Lymphangioleiomyomatosis

Description:

no intervention administered. Recruitment in neurology department

Treatment:

Other: 24h urine

Other: urine sample

Healthy women volunteers

Description:

no intervention administered. Recruitment in clinical investigation centre

Treatment:

Other: 24h urine

Other: urine sample