ClinicalTrials.Veeva

Menu

Lymphatic Function During Mechanical Ventilation (LYMPH-UP)

Rigshospitalet logo

Rigshospitalet

Status

Enrolling

Conditions

Lymphatic Insufficiency

Treatments

Procedure: Elevated pressure ventilation

Study type

Interventional

Funder types

Other

Identifiers

NCT05770752
P-2022-462

Details and patient eligibility

About

This study wil examine the effect of altered intrathoracic pressure on lymphatic function, by investigating the lymphatic vessels in the lower limb during mechanical ventilation.

The lymphatic function will be examined using Near-Infrared Fluorescence Imaging.

Full description

This study wil examine the effect of altered intrathoracic pressure on lymphatic function. This will be done by investigating peripheral lymphatic vessels on patients undergoing surgery for malformations of the jaw who are being mechanically ventilated.

Subjects will be examined on two occasions. One to establish baseline function, and one during surgery following a ventilation protocol with altered PIP and PEEP.

Enrollment

20 estimated patients

Sex

All

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Patients undergoing surgery for jaw malformations
  • Age > 18 years
  • Informed consent
  • Cardiopulmonary healthy

Exclusion criteria

  • History of Cardiac disease
  • History of pulmonary disease
  • History of lymphatic disease
  • Peripheral edema
  • Chronic infectious disease
  • Age > 30 years
  • BMI > 30

Trial design

Primary purpose

Basic Science

Allocation

Non-Randomized

Interventional model

Single Group Assignment

Masking

None (Open label)

Trial contacts and locations

1

Loading...

Central trial contact

Lene Thorup, MD

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems