Lymphatic Function During Mechanical Ventilation (LYMPH-UP)

Rigshospitalet

Status: Enrolling

Conditions: Lymphatic Insufficiency

Treatments: Procedure: Elevated pressure ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT05770752

P-2022-462

Details and patient eligibility

About

This study wil examine the effect of altered intrathoracic pressure on lymphatic function, by investigating the lymphatic vessels in the lower limb during mechanical ventilation.

The lymphatic function will be examined using Near-Infrared Fluorescence Imaging.

Full description

This study wil examine the effect of altered intrathoracic pressure on lymphatic function. This will be done by investigating peripheral lymphatic vessels on patients undergoing surgery for malformations of the jaw who are being mechanically ventilated.

Subjects will be examined on two occasions. One to establish baseline function, and one during surgery following a ventilation protocol with altered PIP and PEEP.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients undergoing surgery for jaw malformations
• Age > 18 years
• Informed consent
• Cardiopulmonary healthy

Exclusion criteria

• History of Cardiac disease
• History of pulmonary disease
• History of lymphatic disease
• Peripheral edema
• Chronic infectious disease
• Age > 30 years
• BMI > 30

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)