Lymphatic Function in Patients With Secondary Tricuspid Valve Regurgitation (LYMTRIVA)

University of Aarhus

Status: Completed

Conditions: Edema; Lymphatic Insufficiency; Heart Failure

Study type: Observational

Funder types: Other

Identifiers

NCT04595448

1-10-72-113-20

Details and patient eligibility

About

The study will examine the lymphatic functional and morphological status in patients with moderate tricuspid valve regurgitation compared to healthy age and gender-matched controls.

The study will use t2 weighted MRI, Near-infrared fluorescence imaging, and plethysmography to examine the above-mentioned question.

Full description

The study will examine the lymphatic functional and morphological status in patients with moderate tricuspid valve regurgitation compared to healthy age and gender-matched controls.

Subjects will be examined at one occasion using t2-weighted MRIs to evaluated lymphatic anatomy and Near-infrared fluorescence imaging for evaluation of superficial peripheral lymphatic function. Finally, the capillary filtration rate will be estimated using plethysmography.

Enrollment: 18 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Patients:

Inclusion criteria:

• Patients with moderate to severe tricuspid regurgitation
• Age ≥18 years
• Informed consent

Exclusion criteria:

• Reduced ejection fraction (<50%)
• Congenital heart disease
• Left sided valve disease
• MRI contraindications (All metal implants, cochlear implants, pacemakers etc.)
• Claustrophobia
• Peripheral edema
• BMI>30
• Age<18.

Controls:

Inclusion criteria:

• Healthy
• Age ≥18 years
• Age, gender and weight matched with included patients.

Exclusion criteria:

• Cardiovascular disease
• MRI contraindications (All metal implants, cochlear implants, pacemakers etc.)
• Claustrophobia
• Peripheral edema
• BMI>30
• Age<18.

Trial design

18 participants in 2 patient groups

Patients

Description:

Patients suffering from moderate tricuspid valve regurgitation

Controls

Description:

Cardiovascular healthy, age, gender and weight matched controls.