Lyspro Insulin vs Regular Insulin in Cirrhotic Patients

University of Campania "Luigi Vanvitelli"

Status and phase: Completed; Phase 4

Conditions: Cirrhosis; Diabetes Mellitus

Treatments: Drug: regular insulin; Drug: lyspro

Study type: Interventional

Funder types: Other

Identifiers

NCT00513201

Second University of Naples

Details and patient eligibility

About

OBJECTIVE: To compare lispro insulin and regular insulin in the glycemic control of patients with liver cirrhosis and type 2 diabetes subjects. METHODS: 108 patients with liver cirrhosis and type 2 diabetes were randomly treated with regular insulin or lispro. After 122 weeks a cross-over was carried out and patients followed-up for 122 weeks. Then, all patients received a standard breakfast of 145 kcal following 12 U.I. of regular insulin or lispro, and C-peptide and insulin serum levels were determined over 300 minutes.

Sex: All

Ages: 48 to 67 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Insulin-treated diabetes mellitus and liver cirrhosis

Exclusion criteria

• Oral hypoglycemic agents treated diabetes mellitus
• Liver cancer