MAC Bipsectral Index Below 50 for Chronic Opioid User

National Cancer Center (NCC)

Status: Unknown

Conditions: Anesthesia

Treatments: Other: History for opioid use

Study type: Interventional

Funder types: Other

Identifiers

NCT02582437

NCC2015-0147

Details and patient eligibility

About

The purpose of this study is to find difference in Minimum Alveolar Concentration(MAC) for maintaining Bispectral Index (BIS) below 50 between chronic opioid users and opioid naive patients.

Full description

1. Patients selection in elective surgery which need general anesthesia.
2. MAC BIS50 data was collected in each patients (by blinded investigator)
3. The data collection will be continued for enough sample size for using Dixon Up Down Method Analysis
4. After Data collection, MAC BIS below 50 will be analyzed in both groups ( Chronic opioid users versus opioid naive patients)

Enrollment: 20 estimated patients

Sex: All

Ages: 41 to 69 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• The patients(ASA class I-III) who receive elective surgery
• signed in informed consent to participate in this trial voluntarily.

Exclusion criteria

• History of Monoamine Oxidase (MAO) inhibitor use
• Chronic alcoholics
• Acute alcohol abuser
• Contraindication for inhalation agent use (Sevoflurane)
• BMI >30
• History of medication use, which affect in the minimum concentration of sevoflurane;(barbiturates, chlorpromazine, diazepam, hydroxyzine, verapamil, marijuana)
• Craniotomy

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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20 participants in 2 patient groups

Chronic Opioid User

Experimental group

Description:

The patients (ASA class I-III) who receive elective surgery s aging between 41 and 69 and signed in informed consent to participate in this trial voluntarily. The Patients who use opioid medication daily and regularly immediately before the day of surgery for more than four weeks. The minimum criteria for opioid dose in the intervention goup is oral morphine 20mg per day: Morphine Equivalent Daily Dose(MEDD)

Treatment:

Other: History for opioid use

Opioid Naive patient

No Intervention group

Description:

The patients (ASA class I-III) who receive elective surgery aging between 41 and 69 and signed in informed consent to participate in this trial voluntarily. The patients who do not use opioid medications immediately before the day of surgery for four weeks.