Machine Learning Predicts Survival and Mutations in Ovarian Metastases of Colorectal Cancer

Sun Yat-sen University

Status: Enrolling

Conditions: Ovarian Metastases of Colorectal Cancer

Treatments: Other: Prediction model

Study type: Observational

Funder types: Other

Identifiers

NCT06192030

wanghm7

Details and patient eligibility

About

The study aimed to develop and validate models to predict survival outcome and key mutations in patients with ovarian metastases of colorectal cancer, as well as to compare the differential gene expression between long-survival group and short-survival group.

Full description

The investigator performed a retrospective-prospective cohort study with the aim of developing and validating comprehensive models to predict survival outcome and key mutations from multimodality data in patients with ovarian metastases of colorectal cancer. Secondly, the investigator aimed to compare the differential gene expression between long-survival group and short-survival group.

Enrollment: 200 estimated patients

Sex: Female

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histologically confirmed colorectal cancer
• Unilateral or bilateral ovarian masses confirmed by peroperative imaging examination
• Patient requiring resection of their ovarian and/or peritoneal carcinomatosis
• 18 ≤ Age ≤ 85
• World Health Organization performance status ≤ 1
• Life expectancy > 12 weeks
• Adequate haematological, liver and renal function
• Patient information and signature of the informed consent form before the start of any treatment procedures

Exclusion criteria

• Ovarian metastases of origin other than colorectal
• Primary ovarian tumor
• Clinical data missing

Trial design

200 participants in 2 patient groups

Retrospective cohort

Description:

The cohort was retrospectively enrolled in The Sixth Affiliated Hospital, Sun Yat-sen University from August 2010 to August 2022. It is a training cohort.

Treatment:

Other: Prediction model

Prospective cohort

Description:

The same inclusion/exclusion criteria were applied for the same center prospectively. It is a validation cohort.

Treatment:

Other: Prediction model