Macronutrients and Gut Hormone Secretion

Lund University

Status: Completed

Conditions: Type 2 Diabetes

Treatments: Other: Macronutrients

Study type: Interventional

Funder types: Other

Identifiers

NCT01366794

005

Details and patient eligibility

About

Study hypothesis is to examine the relative contribution of macronutrients for gut hormone secretion after a mixed meal in healthy volunteers and in subjects with type 2 diabetes. Individual macronutrients or a mixed meal will therefore be served and gut hormones are measured during the following 300 min.

Full description

In healthy volunteers and subjects with dietary regulated diabetes mellitus, glucose, protein mixture or fat emulsion will be served individually and on a separate occasions a mixed meal will be served. Samples will be taken during the following 300 min. Concentrations of the gut hormones glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1, insulin and glucagon will be determined.

Enrollment: 36 estimated patients

Sex: All

Ages: 35 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy status or type 2 diabetes with dietary regulation

Exclusion criteria

• Liver disease
• kidney disease
• thyroid disease

Trial design

36 participants in 2 patient groups

Type 2 diabetes

Experimental group

Description:

Administration of macronutrients in type 2 diabetes

Treatment:

Other: Macronutrients

Healthy volunteers

Experimental group

Description:

Administration of macronutrients in healthy volunteers

Treatment:

Other: Macronutrients