Macronutrients and Satiety in Older and Younger Adults (MACROSAT)

University of Reading

Status: Unknown

Conditions: Gastric Emptying; Appetitive Behavior

Treatments: Other: Smoothie

Study type: Interventional

Funder types: Other

Identifiers

NCT04623450

UREC 19/25

Details and patient eligibility

About

This study aims to compare the effect of meals high in protein, fat and carbohydrate but equal in energy and volume on energy intake, perceived appetite and gastric emptying in younger (<40 years) and older (> 65 years) people living in the United Kingdom (UK).

Full description

To assess if increasing protein intake in older adults will have a compensatory decrease in energy intake due to protein's satiating effects.

To compare the effect of meals high in protein, fat and carbohydrate but equal in energy and volume on energy intake and perceived appetite in younger (<40 years) and older adults (>65 years).

To compare the effect of meals high in protein, fat and carbohydrate but equal in energy and volume on gastric emptying in younger (<40 years) and older adults (>65 years).

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• either aged >65 years or <40 years
• healthy

Exclusion criteria

• having a disease and/or using a medication that can impact on appetite in the past three months;
• having an allergy to any of the test foods;
• disliking or cannot eat any of the test foods;
• being pregnant or breastfeeding;
• being obese (BMI > 30 kg/m2);
• being on a weight loss diet;
• smoking more than 10 cigarettes a day.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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40 participants in 3 patient groups

High Carbohydrate Meal

Experimental group

Description:

A smoothie including maltodextrin and low-fat strawberry yoghurt - 289 kcal, 61g carbohydrate, 6.7g protein, 1.9g fat.

Treatment:

Other: Smoothie

High Fat Meal

Experimental group

Description:

A smoothie including double cream and low-fat strawberry yoghurt - 312 kcal, 13.3g carbohydrate, 7g protein, 25.5g fat.

Treatment:

Other: Smoothie

High Protein Meal

Experimental group

Description:

A smoothie including whey protein and low-fat strawberry yoghurt - 307 kcal, 13.6g carbohydrate, 57g protein, 2.7g fat.

Treatment:

Other: Smoothie