Macroscopic and Molecular Changes in Knee Muscular-tendon Unit in Response to Acute Resistant Load

Hillel Yaffe Medical Center

Status: Unknown

Conditions: Quadriceps Muscle

Treatments: Diagnostic Test: Ultrasound; Other: Acute resistant load exercises; Behavioral: Background Questionnaire; Diagnostic Test: Percutaneous Needle Core Biopsy; Genetic: DNA and RNA test; Other: Pain Questionnaire

Study type: Interventional

Funder types: Other

Identifiers

NCT03950596

HYMC-58-16

Details and patient eligibility

About

The aim of this study is to determine the influence of acute resistance exercises on anatomical and biological changes in the quadriceps muscle and tendons of the knee

Enrollment: 300 estimated patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Non-professional athletes
• Pass heart/lung endurance tests
• Pass ergometrics testing

Exclusion criteria

• Have been injured
• Had physiotherapy for back or lower limbs in past 6 months
• Orthopedic surgery in lower limbs

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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300 participants in 3 patient groups

One acute resistance load exercise

Active Comparator group

Description:

One hundred volunteers will participate in one acute resistance load exercises to their quadriceps

Treatment:

Diagnostic Test: Ultrasound

Other: Pain Questionnaire

Behavioral: Background Questionnaire

Other: Acute resistant load exercises

Diagnostic Test: Percutaneous Needle Core Biopsy

Genetic: DNA and RNA test

Three acute resistance load exercises

Active Comparator group

Description:

One hundred volunteers will participate in three acute resistance load exercises to their quadriceps

Treatment:

Diagnostic Test: Ultrasound

Other: Pain Questionnaire

Behavioral: Background Questionnaire

Other: Acute resistant load exercises

Diagnostic Test: Percutaneous Needle Core Biopsy

Genetic: DNA and RNA test

Control Group

Active Comparator group

Description:

One hundred volunteers will participate in study as a control group

Treatment:

Diagnostic Test: Ultrasound

Other: Pain Questionnaire

Behavioral: Background Questionnaire

Diagnostic Test: Percutaneous Needle Core Biopsy

Genetic: DNA and RNA test