Magnesium and Metabolic Syndrome

Instituto Mexicano del Seguro Social

Status and phase: Completed; Phase 4

Conditions: High Blood Pressure; Diabetes Mellitus; Hypomagnesemia

Treatments: Dietary Supplement: Magnesium chloride; Other: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT00603499

IMSS

2000-161-0027

Details and patient eligibility

About

Objective : to test the BP lowering-effect of oral magnesium supplementation, as magnesium chloride (MgCl2) solution, 2.5 g daily, in uncomplicated hypertensive type 2 diabetic subjects with decreased serum magnesium levels Design : Randomised double blind placebo controlled trial. Setting : Outpatients with type 2 diabetes from Durango, city in northern Mexico Subjects : 82 subjects between 40 and 75 years of age with type 2 diabetes serum magnesium deficiency and uncomplicated hypertension.

Interventions : During 4 months the intervention group received 2.5 gr of magnesium chloride (50 ml of a solution containing 50 gr of MgCl2 by 1000 ml of solution ). Controls received inert placebo.

Main outcome measure: Change in blood pressure. Increase of serum magnesium Secondary outcomes measures: Changes in lipid profile

Enrollment: 85 patients

Sex: All

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Type 2 diabetes
• Decreased serum magnesium levels
• Uncomplicated hypertension
• 40 and 75 years of age
• Men and Women

Exclusion criteria

• Chronic diarrhea
• Alcohol intake (equal or more than 30 g per day)
• Use of diuretics and/or calcium antagonists drugs
• Previous oral magnesium supplementation
• Ischemic diseases; AND
• Reduced renal function

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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85 participants in 2 patient groups, including a placebo group

1

Active Comparator group

Description:

Magnesium chloride

Treatment:

Dietary Supplement: Magnesium chloride

2

Placebo Comparator group

Description:

Placebo

Treatment:

Other: Placebo