Magnesium and Platelet Function Testing (MgCedVD)

East Limburg Hospital

Status: Completed

Conditions: Eclampsia Preeclampsia

Treatments: Other: Collect a study-specific blood sample of healthy subjects

Study type: Observational

Funder types: Other

Identifiers

NCT03143647

CTU2017140

Details and patient eligibility

About

Magnesium has built up the reputation of a 'natural calcium antagonist'. However, the exact effect of magnesium on coagulation and more specifically on platelet function is still disputed. An important discrepancy between in vivo and in vitro studies exists. Magnesium has thus been reported to antagonize platelets in some studies, and to stimulate platelets in other studies. Current evidence seems to point in the direction of a general antagonization of aggregation and coagulation.

Intravenous magnesium is often administered in pre-eclampsia as seizure prophylaxis. Therapeutic regimens usually consist of an intravenously administered loading dose (2-3 grams) and a maintenance infusion, targeting a plasma level of 2-3 mmol/L. Therapeutic drug monitoring is needed, as magnesium toxicity is an important concern.

Enrollment: 20 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Signed Informed consent
• Over 18 years of age (and younger or equal to 50 years of age) and able to provide legally binding consent
• American Society of Anesthesiologists physical fitness scale 1 (non smoker, no or minimal alcohol use, ..)

Exclusion criteria

• Chronic disease
• Chronic medical therapy (other than oral contraception)
• Pregnancy
• ASA 2 or higher
• Known coagulation or aggregation disorders
• Use of COX-inhibitors in the last 10 days
• Contra-indications for venipuncture

Trial design

20 participants in 2 patient groups

Control

Description:

* Female * Over 18 years of age * American Society of Anesthesiologists physical fitness scale 1 * Not pregnant

Treatment:

Other: Collect a study-specific blood sample of healthy subjects

Case

Description:

* Female * Pregnant with possible pre-eclampsia * Over 18 years of age * American Society of Anesthesiologists physical fitness scale 1

Treatment:

Other: Collect a study-specific blood sample of healthy subjects