Magnesium and Postoperative Pain

Seoul National University

Status and phase: Terminated; Phase 4

Conditions: Arthritis Knee; Dexmedetomidine; Magnesium Sulfate

Treatments: Drug: Magnesium Sulfate; Drug: Normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT03253224

B-1707/406-006

Details and patient eligibility

About

With ongoing advancements in healthcare leading to prolonged life expectancy, orthopedic surgeries are increasingly performed in elderly patients. Total knee arthroplasty, in particular, has been increasing with the growing demand for improved mobility and quality of life. Total knee arthroplasty is performed on patients with advanced and painful osteoarthritis of the knees, but it can result in moderate to severe postoperative pain during the recovery period.

To relieve anxiety or stress during surgery under regional anesthesia, sedation can be provided. Dexmedetomidine is a sedative-analgesic agent acting as α2-adrenergic receptor agonist, and its analgesic effect has been well established in various procedures or surgeries.

Magnesium has been reported to produce important analgesic effects including the suppression of neuropathic pain, potentiation of morphine analgesia, and attenuation of morphine tolerance. Although the exact mechanism is not yet fully understood, the analgesic properties of magnesium are believed to stem from regulation of calcium influx into the cell and antagonism of N-methyl-D-aspartate (NMDA) receptors in the central nervous system. In this study, investigators will evaluate the reducing effect of magnesium on the post-total knee arthroplasty pain in patients sedated with dexmedetomidine under spinal anesthesia.

Enrollment: 24 patients

Sex: All

Ages: 50 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who undergo total knee arthroplasty under spinal anesthesia
• Patients who want to sedation during the surgery
• American Society of Anesthesiologists physical status classification 1 and 2

Exclusion criteria

• General anesthesia
• Patients who do not want to sedation during the surgery
• Patients who do not receive patient controlled analgesia postoperatively
• Muscular disease
• Hypermagnesemia
• Atrioventricular block

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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24 participants in 2 patient groups, including a placebo group

Saline

Placebo Comparator group

Description:

Patient who received normal saline during the operation

Treatment:

Drug: Normal saline

Magnesium

Experimental group

Description:

Patient who received magnesium sulfate during the operation

Treatment:

Drug: Magnesium Sulfate