Magnesium and Rotational Thromboelastometry (ROTEM) in Colorectal Cancer Surgery

Seoul National University

Status: Completed

Conditions: Colorectal Cancer

Treatments: Drug: Magnesium Sulfate; Drug: Normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT01938300

Mg-ROTEM-colorectal ca

Details and patient eligibility

About

Magnesium sulphate is given to the patients during the colorectal cancer surgery under the hypothesis that it would attenuate the postoperative hypercoagulability. The investigators intend to characterize the changes of coagulation in colorectal cancer patients by using the point-of-care device after the infusion of magnesium sulphate.

Enrollment: 44 patients

Sex: All

Ages: 20 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The patients undergoing a laparoscopic colorectal cancer surgery

Exclusion criteria

• Renal disease
• Hepatic disease
• Neuromuscular disease
• Coagulation disorder
• Cardiopulmonary disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

44 participants in 2 patient groups, including a placebo group

Magnesium

Experimental group

Description:

Magnesium sulfate infusion during a operation period. Infusion regimen: 1. Bolus 50 mg/kg of magnesium sulfate in 100 ml normal saline over 15 minutes 2. Infusion 15 mg/kg/h of magnesium sulfate throughout the operation

Treatment:

Drug: Magnesium Sulfate

Control

Placebo Comparator group

Description:

administration of normal saline as a same volume of magnesium sulphate as a same method.

Treatment:

Drug: Normal saline