Magnesium Effect on Embryonal PR Interval

Rambam Health Care Campus

Status: Unknown

Conditions: Preterm Labor

Treatments: Diagnostic Test: Trans abdominal sonography

Study type: Interventional

Funder types: Other

Identifiers

NCT03047304

0531-15-RMB

Details and patient eligibility

About

Magnesium is a known treatment for neuroprotection in preterm labor before 32 week of gestation. High concentration of Magnesium in the blood stream known as cause of conduction abnormalities and ECG changes such us prolonged QT, QRS and PR in about. The goal of our work is to evaluate the PR intervals in embryos after maternal treatment with magnesium during preterm labor.

Full description

We will recruit 25 woman with threaten preterm labor, magnesium blood level and PR interval will be evaluated before magnesium loading dose (4gr) and 20 minutes after the loading dose.

PR interval will be evaluated by Mitral-Aorta Doppler.

Enrollment: 25 estimated patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women at risk for preterm labor before 32 week of gestation

Exclusion criteria

• Fetal malformations
• Maternal Lupus
• Fetal conduction abnormalities

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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25 participants in 1 patient group

Women in risk for preterm labor

Other group

Description:

Women in risk for preterm labor treated with magnesium.

Treatment:

Diagnostic Test: Trans abdominal sonography