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Magnesium Nutrition and Sleep Behavior in Older Adults

U

USDA Grand Forks Human Nutrition Research Center

Status

Completed

Conditions

Insomnia
Nutritional Deficiency

Treatments

Dietary Supplement: Sugar Pill
Dietary Supplement: magnesium

Study type

Interventional

Funder types

Other U.S. Federal agency

Identifiers

NCT00833092
GFHNRC014

Details and patient eligibility

About

Insomnia is not a natural part of aging but is higher in older adults because of a variety of factors common in later life. One of these factors may be a deficient magnesium status. This study will look at whether or not magnesium supplementation will improve sleep.

Full description

Insomnia affects approximately one-third of older Americans. More than half of all people aged 65 and older experience sleep problems. The prevalence of insomnia and other sleep disorders is not a natural part of aging but is high in older adults because of a variety of factors common in late life. One of those factors may be a deficient magnesium status. There is a close association between sleep architecture, especially slow wave sleep, and activity in the glutamatergic and gamma-aminobutyric acid (GABA) system. Because magnesium is a natural N-methyl-D-aspartate (NMDA)antagonist and GABA agonist, magnesium apparently plays a key role in the regulation of sleep. Such a role is supported by supplementation, correlation, and animal studies showing that magnesium intake or status affects sleep organization.

Enrollment

111 patients

Sex

All

Ages

51+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • have sleep complaints
  • Score greater than 5 on Pittsburgh Global Sleep Quality Index

Exclusion criteria

  • taking medications that affect sleep
  • taking 100 milligrams or more of magnesium
  • body mass index of 40 or higher
  • abnormal breathing conditions

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

111 participants in 2 patient groups, including a placebo group

Sugar pill
Placebo Comparator group
Description:
Sugar Pill
Treatment:
Dietary Supplement: Sugar Pill
magnesium
Active Comparator group
Description:
300 milligrams of magnesium daily
Treatment:
Dietary Supplement: magnesium

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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