Magnesium Sulfate Combined With Intraarticular Cocktail Injection for Analgesia After Simultaneous Bilateral Total Knee Arthroplasty

Chang Gung Medical Foundation

Status: Not yet enrolling

Conditions: Osteoarthritis, Knee

Treatments: Drug: Magnesium sulfate

Study type: Interventional

Funder types: Other

Identifiers

NCT06445829

202400399A3

Details and patient eligibility

About

Total knee arthroplasty is a safe procedure with excellent outcome. In recent years, simultaneous bilateral total knee arthroplasty has become more popular. In views of enhanced recovery after surgery, intraarticular cocktail injection for pain control has been developed. However, the safety accumulation dose for simultaneous bilateral knee injection is still an issue. Recently, adding magnesium sulfate to intraarticular cocktail injection in unilateral total knee arthroplasty has been proved effective for prolong pain control. We tempt to conduct a double blinded study to evaluate that whether adding magnesium sulfate intraarticular cocktail injection to one of the knees in simultaneous bilateral total knee arthroplasty patient could effectively decrease pain score with less analgesia dose or not.

Enrollment: 80 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• bilateral knee advanced osteoarthritis or osteonecrosis who tend to receive simultaneous bilateral total knee arthroplasty

Exclusion criteria

• hypersensitivity to magnesium sulfate
• hypermagnesemia
• severe cardiac, hepatic or renal compromised

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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80 participants in 2 patient groups

Cocktail injection with Magnesium Sulfate

Experimental group

Description:

Cocktail injection with Marcaine, Dexamethasone, normal saline and Magnesium Sulfate

Treatment:

Drug: Magnesium sulfate

Cocktail injection without Magnesium Sulfate

No Intervention group

Description:

Cocktail injection with Marcaine, Dexamethasone, and normal saline