Magnesium Sulfate Effects on Onset and Duration of Low Dose Rocuronium in Patients Undergoing Laparoscopic Cholecystectomy

Assiut University

Status and phase: Unknown; Phase 2

Conditions: Muscle Relaxation

Treatments: Drug: Saline; Drug: Standard dose Rocuronium; Drug: Magnesium Sulfate; Drug: Low dose Rocuronium

Study type: Interventional

Funder types: Other

Identifiers

NCT02669368

01MgRo

Details and patient eligibility

About

This study aims to evaluate effects of magnesium sulfate on onset and duration of low dose rocuronium, intubation condition and surgical condition in patients undergoing laparoscopic cholecystectomy.

Enrollment: 75 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists physical status 1 or 2.
• BMI of 25-34.9 kg/m2.
• Patients scheduled for laparoscopic cholecystectomy.

Exclusion criteria

• Severe respiratory or cardiac disease.
• Hepatic or renal function impairment.
• Neuromuscular disease.
• Patients on medications affecting neuromuscular function.
• Patients with known allergy to the drugs.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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75 participants in 3 patient groups

Standard dose Rocuronium

Active Comparator group

Description:

Pretreatment of saline 100ml then giving Rocuronium 0.6 mg/kg at induction of anesthesia.

Treatment:

Drug: Standard dose Rocuronium

Drug: Saline

Low dose Rocuronium

Active Comparator group

Description:

Pretreatment of saline 100ml then giving Rocuronium 0.45 mg/kg at induction of anesthesia.

Treatment:

Drug: Low dose Rocuronium

Drug: Saline

Low dose Rocuronium + Magnesium Sulfate

Active Comparator group

Description:

Pretreatment of Magnesium sulfate 30 mg/kg then giving Rocuronium 0.45 mg/kg at induction of anesthesia.

Treatment:

Drug: Low dose Rocuronium

Drug: Magnesium Sulfate