Magnesium Sulfate Effects on Onset and Duration of Low Dose Rocuronium in Patients Undergoing Laparoscopic Cholecystectomy

A

Assiut University

Status and phase

Unknown
Phase 2

Conditions

Muscle Relaxation

Treatments

Drug: Saline
Drug: Standard dose Rocuronium
Drug: Magnesium Sulfate
Drug: Low dose Rocuronium

Study type

Interventional

Funder types

Other

Identifiers

NCT02669368
01MgRo

Details and patient eligibility

About

This study aims to evaluate effects of magnesium sulfate on onset and duration of low dose rocuronium, intubation condition and surgical condition in patients undergoing laparoscopic cholecystectomy.

Enrollment

75 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • American Society of Anesthesiologists physical status 1 or 2.
  • BMI of 25-34.9 kg/m2.
  • Patients scheduled for laparoscopic cholecystectomy.

Exclusion criteria

  • Severe respiratory or cardiac disease.
  • Hepatic or renal function impairment.
  • Neuromuscular disease.
  • Patients on medications affecting neuromuscular function.
  • Patients with known allergy to the drugs.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

75 participants in 3 patient groups

Standard dose Rocuronium
Active Comparator group
Description:
Pretreatment of saline 100ml then giving Rocuronium 0.6 mg/kg at induction of anesthesia.
Treatment:
Drug: Standard dose Rocuronium
Drug: Saline
Low dose Rocuronium
Active Comparator group
Description:
Pretreatment of saline 100ml then giving Rocuronium 0.45 mg/kg at induction of anesthesia.
Treatment:
Drug: Low dose Rocuronium
Drug: Saline
Low dose Rocuronium + Magnesium Sulfate
Active Comparator group
Description:
Pretreatment of Magnesium sulfate 30 mg/kg then giving Rocuronium 0.45 mg/kg at induction of anesthesia.
Treatment:
Drug: Low dose Rocuronium
Drug: Magnesium Sulfate

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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