Magnesium Sulfate Versus Nifedipine for the Acute Tocolysis of Preterm Labor: A Prospective, Randomized Trial

Stanford University

Status: Completed

Conditions: Obstetric Labor, Premature

Treatments: Drug: Nifedipine; Drug: Magnesium Sulfate

Study type: Interventional

Funder types: Other

Identifiers

NCT00185900

76145

Details and patient eligibility

About

To compare intravenous magnesium sulfate to oral nifedipine for acute tocolysis of preterm labor

Enrollment: 192 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria::- Uterine contractions and cervical change or ruptured membranes in a preterm gestation Exclusion Criteria:- placental abruption, fetal distress, placenta previa, maternal medical contraindication to tocolysis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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192 participants in 2 patient groups

Magnesium Sulfate

Active Comparator group

Description:

Preterm labor treatment with Magnesium Sulfate.

Treatment:

Drug: Magnesium Sulfate

Nifedipine

Active Comparator group

Description:

Preterm labor treatment with Nifedipine.

Treatment:

Drug: Nifedipine