Magnesium Sulfate vs Placebo for Placental Abruption

Stanford University

Status: Completed

Conditions: Abruptio Placentae

Treatments: Other: Normal Saline; Drug: Magnesium Sulfate

Study type: Interventional

Funder types: Other

Identifiers

NCT00186069

79811

Details and patient eligibility

About

To evaluate the safety and efficacy of magnesium sulfate for preterm suspected abruption.

Full description

We hope to learn if there is a difference in the efficacy of intravenous magnesium sulfate versus intravenous saline infusion in the resolution of vaginal bleeding and contractions in patients with a suspected placental abruption.

Enrollment: 30 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• vaginal bleeding and contractions consistent with suspected placental abruption between 24 and 34 weeks gestation.

Exclusion criteria

• preterm labor, severe bleeding necessitating immediate delivery, maternal coagulopathy, fetal distress

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Double Blind

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30 participants in 2 patient groups, including a placebo group

Magnesium Sulfate

Active Comparator group

Description:

Magnesium Sulfate 4 gram bolus, followed by 2 grams per hour

Treatment:

Drug: Magnesium Sulfate

Normal Saline

Placebo Comparator group

Description:

Normal Saline 4 gram bolus, followed by 2 grams per hour

Treatment:

Other: Normal Saline