Magnesium Sulphate Injection in Treatment of Myofascial Trigger Points

Fayoum University

Status and phase

Completed

Phase 4

Conditions

Trigger Point Pain, Myofascial

Treatments

Drug: Saline

Drug: Magnesium sulfate

Study type

Interventional

Funder types

Other

Identifiers

NCT04742140

Mg SO4 injections

Details and patient eligibility

About

This is a prospective, single- center, randomized (1:1) clinical trial comparing the effectiveness of magnesium sulphate injections in treatment of myofascial trigger points in the masseter muscle versus the saline injection.

Full description

The proposal presents the magnesium sulphate (MgSO4) as a possible injection treatment for TrPs. The MgSO4 prevents the release of pre-synaptic acetylcholine from neuromuscular and sympathetic junctions that could explain the ability of the MgSO4 to relax the muscle and reduce pain Specific aim: evaluate the effectiveness of magnesium sulphate injections in treatment of myofascial trigger points in the masseter muscle versus the saline injection.

Hypothesis: the injection of masseter muscle trigger points with magnesium sulphate is more effective than saline injection in pain relief.

Enrollment

180 patients

Sex

All

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Definite diagnosis of myofascial pain with a referral, based on the DC/TMD criteria
the presence of one or more trigger points in the unilateral or bilateral masseter muscle
no history of any invasive procedures in the related masseter muscle.

Exclusion criteria

Factors that can cause pain in the orofacial region other than MTPs (decayed tooth, TMJ internal disorder).
Any systemic disease that possibly affects the masticatory system such as rheumatoid arthritis and epilepsy
pregnancy and lactation.