Magnesium Supplementation in Simultaneous Pancreas-Kidney Transplantation

Dr Olu Bamgbade, MD, FRCPC

Status

Completed

Conditions

Pancreas Transplantation

Transplantation, Kidney

Pancreatic Insufficiency (Exocrine and Endocrine)

Diabetes Mellitus, with Complications

Glomerulosclerosis

Renal Failure Chronic Requiring Dialysis

Treatments

Drug: Magnesium Sulfate high dose

Study type

Observational

Funder types

Other

Identifiers

NCT06766786

SalemAne Magnesia SPK Transpl

Details and patient eligibility

About

Magnesium is essential in human physiology. Simultaneous pancreas-kidney (SPK) transplant recipients frequently experience hypomagnesemia. The effects of hypomagnesaemia are harmful. This observational study assessed intraoperative magnesium supplementation's utility in patients undergoing SPK transplantation. Perioperative hemodynamics were monitored. Postoperative serum magnesium was monitored at 12 hours and 48 hours.

Full description

A vital component of human physiology is magnesium. It is common for recipients of simultaneous pancreas-kidney (SPK) transplants to have hypomagnesemia. The consequences of hypomagnesaemia are detrimental. This prospective observational study evaluated the effectiveness and safety of intraoperative magnesium supplementation in adult SPK transplant recipients. Arrhythmia and perioperative hemodynamics were observed. Serum magnesium levels were checked 12 and 48 hours after surgery.

Enrollment

40 patients

Sex

All

Ages

20 to 99 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adult diabetic patients who require insulin therapy and hemodialysis due to pancreatic-kidney failure.

Exclusion criteria

Adult diabetic patients who do not require insulin therapy and hemodialysis.

Trial design

40 participants in 1 patient group

Chronic pancreas-kidney failure.

Description:

Adult patients with diabetes mellitus and chronic pancreas-kidney failure who require insulin and hemodialysis therapy. Intravenous magnesium supplementation was given intraoperatively to consenting patients receiving simultaneous pancreas-kidney (SPK) transplantation.

Treatment:

Drug: Magnesium Sulfate high dose