Magnesium Supplementation in Simultaneous Pancreas-Kidney Transplantation

Dr Olu Bamgbade, MD, FRCPC

Status: Completed

Conditions: Pancreas Transplantation; Transplantation, Kidney; Pancreatic Insufficiency (Exocrine and Endocrine); Diabetes Mellitus, with Complications; Glomerulosclerosis; Renal Failure Chronic Requiring Dialysis

Treatments: Drug: Magnesium Sulfate high dose

Study type: Observational

Funder types: Other

Identifiers

NCT06766786

SalemAne Magnesia SPK Transpl

Details and patient eligibility

About

Magnesium is essential in human physiology. Simultaneous pancreas-kidney (SPK) transplant recipients frequently experience hypomagnesemia. The effects of hypomagnesaemia are harmful. This observational study assessed intraoperative magnesium supplementation's utility in patients undergoing SPK transplantation. Perioperative hemodynamics were monitored. Postoperative serum magnesium was monitored at 12 hours and 48 hours.

Full description

A vital component of human physiology is magnesium. It is common for recipients of simultaneous pancreas-kidney (SPK) transplants to have hypomagnesemia. The consequences of hypomagnesaemia are detrimental. This prospective observational study evaluated the effectiveness and safety of intraoperative magnesium supplementation in adult SPK transplant recipients. Arrhythmia and perioperative hemodynamics were observed. Serum magnesium levels were checked 12 and 48 hours after surgery.

Enrollment: 40 patients

Sex: All

Ages: 20 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult diabetic patients who require insulin therapy and hemodialysis due to pancreatic-kidney failure.

Exclusion criteria

• Adult diabetic patients who do not require insulin therapy and hemodialysis.

Trial design

40 participants in 1 patient group

Chronic pancreas-kidney failure.

Description:

Adult patients with diabetes mellitus and chronic pancreas-kidney failure who require insulin and hemodialysis therapy. Intravenous magnesium supplementation was given intraoperatively to consenting patients receiving simultaneous pancreas-kidney (SPK) transplantation.

Treatment:

Drug: Magnesium Sulfate high dose